Using serial ports from Linux is easy and robust. Serial ports work in WINE as well. PuTTY has GUI configuration for serial ports.
apt install putty
Minicom or screen are less user-friendly in my opinion.
Regardless of which serial port program is used, add the user to the “dialout” group for non-root access to serial ports (one-time)
adduser $(whoami) dialout
Then logout and login.
Here’s an example PuTTY configuration for a 115200 baud serial port device.
PuTTY for Windows get “64-bit MSI”
List hardware serial ports (motherboard or PCI card):
apt install setserial setserial -g /dev/ttyS* | grep -v unknown
List the USB-serial adapter ports: